The combination of six high-quality branded ingredients

MSM GC Plus is the most comprehensive formula within the Kala Health product line for natural mobility. This formula combines no fewer than six different high-quality ingredients: MSM, glucosamine, chondroitin, vitamin C, undenatured type II collagen and seawater concentrate. Only patented branded ingredients have been used, guaranteeing the highest quality and biological efficacy: OptiMSM®, NaturGlux®, ChondroPure®, Ester-C®, Collavant® and Aquamin®.

This choice for quality is not arbitrary. Extensive scientific research has been conducted on MSM, glucosamine, chondroitin and collagen. This research shows that the purity of the ingredients used has a greater impact on results than the specific form. Contaminated or inferior ingredients simply do not deliver the same results as pharmaceutical-grade ingredients. That is why Kala Health selects only branded ingredients that have been extensively tested for both the presence of pure active substances and the absence of contaminants.

A distinctive feature of MSM GC Plus is that the formula contains no fillers. While many supplements contain bulking agents, binders and anti-caking agents, MSM GC Plus uses all space in the vegetarian capsule for active ingredients. This is possible because the six branded ingredients are so pure that they require no additional excipients for processing. The result is a formula where every milligram counts.

The formula contains vitamin C in the form of Ester-C®, which contributes to normal collagen formation for the normal function of cartilage and bones. This makes MSM GC Plus a complete formula for anyone who wants to optimally support their body with an active lifestyle.

The six branded ingredients explained

OptiMSM® – The purest form of MSM

OptiMSM® is the purest form of MSM on the market. MSM is a very small, light molecule, which makes it easily absorbed by the body. MSM is the form in which sulphur naturally occurs in all living organisms and in which it is biologically active. In nature, MSM is found in fruits, vegetables and in the milk of grazing cows. Each MSM GC Plus capsule contains 300 mg OptiMSM®.

NaturGlux® – Plant-based glucosamine

Glucosamine is a substance that occurs naturally in the human body. It is also found in the shells of shellfish such as shrimp, crabs and lobsters. These shells contain chitin, a polysaccharide that can be converted into glucosamine. However, NaturGlux® glucosamine is of plant origin and is produced by fermentation of corn. This makes the formula free from common allergens associated with shellfish – an important benefit for people with allergies. Each capsule contains 225 mg NaturGlux® glucosamine HCl, which corresponds to 188 mg elemental glucosamine.

ChondroPure® – Optimal molecular size for absorption

Chondroitin is present in foods with a high cartilage content, particularly from animals such as cattle, pigs and sharks. The cartilage of these animals contains chondroitin sulphate, a compound that is extracted for use in food supplements. ChondroPure® chondroitin is sourced from bovine trachea. The molecules are relatively small (< 10,000 daltons), which is crucial for effective absorption by the body. Each capsule contains 200 mg ChondroPure® chondroitin sulphate.

Ester-C® – Stomach-friendly vitamin C

The MSM GC Plus formula deliberately uses the form of vitamin C known as Ester-C® (calcium ascorbate). This patented form of vitamin C is characterised by improved absorption and a gentler effect on the stomach compared to traditional ascorbic acid. Each capsule contains 60 mg Ester-C®, which corresponds to 75% of the reference intake.

Collavant® – Undenatured type II collagen

Collavant® is an undenatured type II collagen, sourced from chicken sternum cartilage (breastbone cartilage). Type II collagen occurs naturally in the cartilage of vertebrates and is the most common type of collagen in joint cartilage.

What makes undenatured collagen special is its fundamentally different mechanism of action compared to hydrolysed collagen:

Each MSM GC Plus capsule contains 15 mg Collavant® undenatured type II collagen. This may seem little compared to the grams of hydrolysed collagen in some products, but is consistent with the specific mechanism of action of undenatured collagen.

Aquamin® – Seawater concentrate with 80 natural minerals

Aquamin® MG TG is a unique mineral complex harvested from the deep, pure waters of the Atlantic Ocean off the coast of Ireland. The source is Lithothamnion calcareum, a red algae that absorbs and stores minerals from seawater in its cell structure during its life cycle.

Each MSM GC Plus capsule contains 50 mg Aquamin® MG TG, adding a broad base of natural minerals and trace elements to the formula.

Why no fillers?

An important distinguishing feature of MSM GC Plus is the absence of fillers. Most food supplements contain various excipients in addition to active ingredients:

• Bulking agents – to bring the capsule or tablet to weight
• Binders – to hold ingredients together
• Anti-caking agents – to ensure smooth production
• Lubricants – to keep machinery functioning properly

With MSM GC Plus, these excipients are not needed. The six branded ingredients are so pure and have such good processing properties that they can be encapsulated without additives. The result: a vegetarian capsule of 975 mg in which every milligram consists of active ingredients.

The MSM GC Product Line: three formulas for natural mobility

The Kala Health product line for natural mobility consists of three different formulas, each with its own combination of high-quality branded ingredients. MSM GC Plus capsules form the most comprehensive formula within this line, with six branded ingredients including undenatured type II collagen and seawater concentrate.

For those looking for a basic formula, there is MSM GC tablets with MSM, glucosamine, chondroitin and vitamin C. Additionally, there is MSM GC Vegan, with plant-based chondroitin (MythoCondro®) instead of animal-derived chondroitin, making this formula fully suitable for vegetarians and vegans.

What is MSM?

MSM stands for methylsulfonylmethane, an organically bound form of sulphur. It is a natural substance that occurs naturally in various foods such as fresh fruit and vegetables. Remarkably, breast milk is the richest natural source of MSM. As we age, the amount of MSM in the human body decreases.

MSM is a very small, light molecule. This makes MSM easy for the body to absorb. MSM is the form in which sulphur naturally occurs in all living organisms and in which it is biologically active. However, through food processing, heating and storage, the MSM content in food decreases rapidly, which is why supplementation may be interesting for many people.

The recommended dosage for most people varies between 2 and 8 grams of MSM per day, depending on individual needs and goals.

What is Glucosamine and which form is best?

Glucosamine is a naturally occurring substance in the human body. Glucosamine as a molecule is inherently unstable and is converted into a ‘salt’ by binding with another molecule. The most common glucosamine salts on the market are:

• Glucosamine sulphate.2KCl
• Glucosamine sulphate.NaCl
• Glucosamine HCl

There is some uncertainty about which of these three forms is most effective. However, many scientists agree that the specific form of the salt should not be of great importance. In the acidic environment of the stomach, the salt breaks down into a glucosamine molecule and a residual group. The glucosamine molecule is then absorbed in the intestine, while the remaining molecule completely disappears among the numerous hydrochloric acid molecules (-HCl) in the gastric juice.

Scientific research on bioavailability

Aghazadeh et al. (2011) orally administered rats an equal dose of glucosamine of both forms. The glucosamine sulphate.NaCl used was a patented, pharmaceutical-grade product from Rottapharm, while the glucosamine HCl used was high-quality and plant-based. The results showed that the change in plasma concentration of glucosamine over time was virtually identical.

The same authors also examined the excretion of glucosamine in the urine of four human volunteers after oral intake of 1500 mg glucosamine sulphate.NaCl (Rottapharm) or high-quality glucosamine HCl. The results showed that the excretion of both forms was almost identical. The authors concluded that both the absorption and excretion of the glucosamine sulphate.NaCl and glucosamine HCl used are identical and show no difference in bioavailability for the body.

Glucosamine HCl contains more elemental glucosamine

Since differences in bioavailability are excluded, it becomes interesting to look at the economic aspects. A sulphate group has considerably more weight than an HCl group. This becomes clear in the percentage of elemental glucosamine:

In other words: to consume a comparable amount of elemental glucosamine, you would need to take 41% and 32% more glucosamine sulphate.2KCl and glucosamine sulphate.NaCl respectively than glucosamine HCl.

What is Chondroitin?

Chondroitin, more precisely chondroitin sulphates, consist of elongated chains of interconnected molecules of galactosamine sulphate and glucuronic acid. They form the essential chains of glycosaminoglycans (GAG).

For a long time, it was thought that chondroitin molecules were too large to be absorbed by the body, which meant that intake was considered pointless. Recently, however, this view has been nuanced, as small chondroitin molecules are indeed absorbed intact by the body.

Where does Chondroitin come from?

Chondroitin is mainly commercially obtained from animal cartilage, sourced from cattle. The effectiveness of chondroitin is strongly linked to its concentration and quality. Due to the costliness of this substance, it is often ‘diluted’. Many cheap ‘chondroitin’ preparations on the market contain only a limited percentage of actual chondroitin.

Benefits of MSM GC Plus: the role of Vitamin C

MSM GC Plus contains vitamin C in the form of Ester-C®. Although extensive scientific research has been conducted on MSM, glucosamine, chondroitin and collagen, the European Union has not (yet) approved health claims for these substances. Vitamin C is the only ingredient in this formula for which the EFSA (European Food Safety Authority) has approved health claims:

One MSM GC Plus capsule contains 60 mg of vitamin C, which corresponds to 75% of the reference intake. At the recommended dosage of 2 capsules per day, 150% of the daily reference intake is achieved.

Natural food sources

MSM in food

MSM occurs naturally in fresh fruit, fresh vegetables and in the milk of grazing cows. Breast milk is the richest natural source of MSM. However, through food processing, heating and storage, the MSM content in food decreases rapidly.

Glucosamine in food

Glucosamine does not occur directly in the food we eat daily. The human body produces glucosamine itself. Traditionally, glucosamine for supplements is obtained from the shells of shellfish, but NaturGlux® is produced by fermentation of plant-based corn.

Chondroitin in food

Chondroitin is present in foods with a high cartilage content, particularly from animals such as cattle, pigs and sharks. Eating cartilage (for example from chicken bones or in bone broth) provides small amounts of chondroitin. However, the concentrations are much lower than in concentrated supplements.

Collagen in food

Type II collagen occurs naturally in cartilage-rich foods, particularly in chicken cartilage, fish bones and broth made from bones and cartilage. However, the collagen in food is largely denatured by heating. Undenatured type II collagen such as Collavant® retains its natural structure.

Quality and purity: tested in independent laboratory

At Kala Health, we make no compromises on quality. Every batch of MSM GC Plus capsules is extensively tested in an independent laboratory before leaving our factory. We check for three crucial points:

• Free from harmful bacteria: tested for pathogens such as E. coli (< 3 cfu/g), Salmonella (negative), Staphylococcus aureus (< 3 cfu/g) and Pseudomonas aeruginosa (< 10 cfu/g)
• Free from heavy metals: lead (< 3.0 ppm), cadmium (< 1.0 ppm), mercury (< 0.1 ppm) and arsenic (< 0.3 ppm) remain well below European safety limits in accordance with EC 629/2008 and EC 1006/2015
• Microbiologically pure: total plate count < 1000 cfu/g, yeast and mould < 10 cfu/g according to strict international standards

The result is a supplement you can fully trust. The complete Product Specification Sheet with all test results is available upon request.

In-house production

MSM GC Plus capsules are fully manufactured in our own FSSC 22000-certified factory in the Netherlands. From raw material analysis to capsule filling and packaging: everything is done in-house, under the direct supervision of our quality team. Thanks to this complete supply chain control, we guarantee purity, safety and traceability in every step of the process.

Certifications and guarantees

MSM GC Plus capsules meet international quality and safety standards:

• FSSC 22000 certified: manufactured in our own certified Dutch facility according to the highest food safety standards
• GMO-free: certified in accordance with EC 1830/2003 – no genetically modified ingredients
• Non-irradiated: in accordance with EC 1999/2 – no ionising radiation applied
• Vegetarian capsule: transparent HPMC capsule, suitable for vegetarians
• Free from shellfish allergens: thanks to plant-based NaturGlux® glucosamine
• No fillers: all space in the capsule used for active ingredients
• Guaranteed free from: preservatives, synthetic fragrances, colours and flavourings

Who is MSM GC Plus suitable for?

MSM GC Plus capsules have been developed for:

• People who want to support their natural mobility with the most comprehensive formula
• Active athletes and people with an active lifestyle
• Individuals looking for a combination of MSM, glucosamine, chondroitin and undenatured type II collagen
• People with a shellfish allergy (thanks to plant-based glucosamine)
• Users who value a formula without fillers
• Anyone looking for a premium quality product made in the Netherlands

Not suitable for

• Children and adolescents under 18 years of age
• Pregnant or breastfeeding women (consult a doctor first)
• People taking blood thinners (consult a doctor first due to chondroitin)
• People with an allergy to chicken or chicken products (due to Collavant® collagen from chicken cartilage)
• People with an allergy to beef or beef products (due to ChondroPure® chondroitin from bovine trachea)
• Vegans (chondroitin and collagen are of animal origin) – choose MSM GC Vegan

Product features at a glance

• Six patented branded ingredients – OptiMSM®, NaturGlux®, ChondroPure®, Ester-C®, Collavant® and Aquamin®
• No fillers – all space used for active ingredients
• Vegetarian capsule – transparent HPMC capsule (size 00)
• Manufactured in the Netherlands – in our own FSSC 22000-certified factory
• Complete supply chain control – from raw material to finished product under direct supervision
• Extensively tested – for heavy metals and microbiological purity in independent laboratory
• GMO-free and non-irradiated – in accordance with EU legislation (EC 1830/2003 and EC 1999/2)
• Capsule specifications: size 00, transparent, 975 mg per capsule

Important notices

A food supplement is not a substitute for a varied diet. A varied, balanced diet and a healthy lifestyle are important. This product is a food supplement (contains MSM, glucosamine, chondroitin, undenatured type II collagen, vitamins and minerals).

Safety: Consult a healthcare professional before using supplements in case of pregnancy, breastfeeding (lactation), medication use or illness.

Storage advice: Store in a cool, dry place, out of reach of small children.

Due to legal restrictions, we may not disclose all details about the possible effects of this food supplement. For content-related questions or personal advice, please contact us by phone: (+31) 070-345-0290. Or by email: info@kalahealth.eu.