The combination of MSM, Glucosamine, Chondroitin and Vitamin C

MSM GC combines the power of four carefully selected ingredients: MSM, glucosamine, chondroitin and vitamin C. This formula has been specially developed by Kala Health’s product developers to support natural mobility. What makes MSM GC unique is that only high-quality, patented branded ingredients are used: OptiMSM®, NaturGlux®, ChondroPure® and Ester-C®.

This choice for quality is not arbitrary. Extensive scientific research has been conducted on MSM, glucosamine and chondroitin. This research shows that the purity of the ingredients used has a greater impact on results than the specific form. Contaminated or inferior ingredients simply do not deliver the same results as pharmaceutical-grade ingredients. That is why Kala Health selects only branded ingredients that have been extensively tested for both the presence of pure active substances and the absence of contaminants.

The formula contains vitamin C in the form of Ester-C®, which contributes to normal collagen formation for the normal function of cartilage and bones. This makes MSM GC a complete formula for anyone who wants to optimally support their body with an active lifestyle.

The four branded ingredients explained

OptiMSM® – The purest form of MSM

OptiMSM® is the purest form of MSM on the market. MSM is a very small, light molecule, which makes it easily absorbed by the body. MSM is the form in which sulphur naturally occurs in all living organisms and in which it is biologically active. In nature, MSM is found in fruits, vegetables and in the milk of grazing cows. Each MSM GC tablet contains 400 mg OptiMSM®.

NaturGlux® – Plant-based glucosamine

Glucosamine is a naturally occurring substance in the human body. It is also found in the shells of shellfish such as shrimp, crabs and lobsters. These shells contain chitin, a polysaccharide that can be converted into glucosamine. However, NaturGlux® glucosamine is of plant origin, produced by fermentation of corn. This makes the formula free from common shellfish allergens, an important benefit for people with allergies. Each tablet contains 250 mg NaturGlux® glucosamine HCl, which corresponds to 209 mg elemental glucosamine.

ChondroPure® – Optimal molecular size for absorption

Chondroitin is found in cartilage-rich foods, particularly from animals such as cattle, pigs and sharks. The cartilage of these animals contains chondroitin sulphate, a compound that is extracted for use in supplements. ChondroPure® chondroitin is sourced from bovine trachea. The molecules are relatively small (< 10,000 daltons), which is important for good absorption. Each tablet contains 225 mg ChondroPure® chondroitin sulphate.

Ester-C® – Stomach-friendly vitamin C

The MSM GC formula deliberately uses the vitamin C form called Ester-C® (calcium ascorbate). This patented form of vitamin C is characterised by better absorption and stomach-friendliness compared to traditional ascorbic acid. Each tablet contains 60 mg Ester-C®, which corresponds to 75% of the reference intake.

The MSM GC Product Line: Three formulas for natural mobility

The Kala Health product line for natural mobility consists of three different formulas, each with its own combination of high-quality branded ingredients. MSM GC tablets form the foundation of this line: a powerful combination of MSM, glucosamine, chondroitin and vitamin C in tablet form.

For those looking for a more comprehensive formula, Kala Health also offers MSM GC Plus capsules, with added undenatured type II collagen (Collavant®) and seawater concentrate (Aquamin®). Additionally, there is MSM GC Vegan, with plant-based chondroitin (MythoCondro®) instead of animal-derived chondroitin, making this formula fully suitable for vegetarians and vegans.

What is MSM?

MSM stands for methylsulfonylmethane, an organically bound form of sulphur. It is a natural substance that occurs naturally in various foods such as fresh fruit and vegetables. Remarkably, breast milk is the richest natural source of MSM. As we age, the amount of MSM in the human body decreases.

MSM is a very small, light molecule. This makes MSM easy for the body to absorb. MSM is the form in which sulphur naturally occurs in all living organisms and in which it is biologically active. However, through food processing, heating and storage, the MSM content in food decreases rapidly, which is why supplementation may be interesting for many people.

The recommended dosage for most people varies between 2 and 8 grams of MSM per day, depending on individual needs and goals.

What is Glucosamine and which form is best?

Glucosamine is a naturally occurring substance in the human body. Glucosamine as a molecule is inherently unstable and is converted into a ‘salt’ by binding with another molecule. The most common glucosamine salts on the market are:

• Glucosamine sulphate.2KCl
• Glucosamine sulphate.NaCl
• Glucosamine HCl

There is some uncertainty about which of these three forms is most effective. However, many scientists agree that the specific form of the salt should not be of great importance. In the acidic environment of the stomach, the salt breaks down into a glucosamine molecule and a residual group. The glucosamine molecule is then absorbed in the intestine, while the remaining molecule completely disappears among the numerous hydrochloric acid molecules (-HCl) in the gastric juice.

The dosing protocol of Glucosamine

Furthermore, the intake protocols in the studies were not uniform. Most studies used an intake schedule of three times daily 500 mg, while successful glucosamine sulphate.NaCl studies were conducted with an intake of 1500 mg once daily. Different intake patterns can lead to different pharmacokinetic profiles of glucosamine in the body, making comparison of such studies difficult.

Scientific research on bioavailability

Aghazadeh et al. (2011) orally administered rats an equal dose of glucosamine of both forms. The glucosamine sulphate.NaCl used was a patented, pharmaceutical-grade product from Rottapharm, while the glucosamine HCl used was high-quality and plant-based. The results showed that the change in plasma concentration of glucosamine over time was virtually identical.

The same authors also examined the excretion of glucosamine in the urine of four human volunteers after oral intake of 1500 mg glucosamine sulphate.NaCl (Rottapharm) or high-quality glucosamine HCl. The results showed that the excretion of both forms was almost identical. The authors concluded that both the absorption and excretion of the glucosamine sulphate.NaCl and glucosamine HCl used are identical and show no difference in bioavailability for the body.

Glucosamine HCl contains more elemental glucosamine

Since differences in bioavailability are excluded, it becomes interesting to look at the economic aspects. A sulphate group has considerably more weight than an HCl group. This becomes clear in the percentage of elemental glucosamine:

In other words: to consume a comparable amount of elemental glucosamine, you would need to take 41% and 32% more glucosamine sulphate.2KCl and glucosamine sulphate.NaCl respectively than glucosamine HCl.

What is Chondroitin?

Chondroitin, more precisely chondroitin sulphates, consist of elongated chains of interconnected molecules of galactosamine sulphate and glucuronic acid. They form the essential chains of glycosaminoglycans (GAG).

For a long time, it was thought that chondroitin molecules were too large to be absorbed by the body, which meant that taking them was considered pointless. Recently, however, this view has been nuanced, as small chondroitin molecules are indeed absorbed intact by the body.

Where does Chondroitin come from?

Chondroitin is mainly commercially obtained from animal cartilage, sourced from cattle. The effectiveness of chondroitin is strongly linked to its concentration and quality. Due to the costliness of this substance, it is often ‘diluted’. Many cheap ‘chondroitin’ preparations on the market contain only a limited percentage of actual chondroitin.

Benefits of MSM GC: The role of Vitamin C

MSM GC contains vitamin C in the form of Ester-C®. Although extensive scientific research has been conducted on MSM, glucosamine and chondroitin, the European Union has not (yet) approved health claims for these substances. Vitamin C is the only ingredient in this formula for which the EFSA (European Food Safety Authority) has approved health claims:

One MSM GC tablet contains 60 mg of vitamin C, which corresponds to 75% of the reference intake. At the recommended dosage of 2 tablets per day, 150% of the daily reference intake is achieved.

Natural food sources

MSM in food

MSM occurs naturally in fresh fruit, fresh vegetables and in the milk of grazing cows. Breast milk is the richest natural source of MSM. However, through food processing, heating and storage, the MSM content in food decreases rapidly.

Glucosamine in food

Glucosamine does not occur directly in the food we eat daily. The human body produces glucosamine itself. Traditionally, glucosamine for supplements is obtained from the shells of shellfish, but NaturGlux® is produced by fermentation of plant-based corn.

Chondroitin in food

Chondroitin is found in cartilage-rich foods, particularly from animals such as cattle, pigs and sharks. Eating cartilage (for example from chicken bones or in bone broth) provides small amounts of chondroitin. However, the concentrations are much lower than in concentrated supplements.

Quality and purity: Tested in independent laboratory

At Kala Health, we make no compromises on quality. Every batch of MSM GC tablets is extensively tested in an independent laboratory before leaving our factory. We check for three crucial points:

• Free from harmful bacteria: tested for pathogens such as E. coli (< 3 cfu/g), Salmonella (negative), Staphylococcus aureus (< 3 cfu/g) and Pseudomonas aeruginosa (< 10 cfu/g)
• Free from heavy metals: lead (< 3.0 ppm), cadmium (< 1.0 ppm), mercury (< 0.1 ppm) and arsenic (< 0.3 ppm) remain well below European safety limits in accordance with EC 629/2008 and EC 1006/2015
• Microbiologically pure: total plate count < 1000 cfu/g, yeast and mould < 10 cfu/g according to strict international standards

The result is a supplement you can fully trust. The complete Product Specification Sheet with all test results is available upon request.

In-house production

MSM GC tablets are fully manufactured in our own FSSC 22000-certified factory in the Netherlands. From raw material analysis to tableting and packaging: everything is done in-house, under the direct supervision of our quality team. Thanks to this complete supply chain control, we guarantee purity, safety and traceability in every step of the process.

Certifications and guarantees

MSM GC tablets meet international quality and safety standards:

• FSSC 22000 certified: manufactured in our own certified Dutch facility according to the highest food safety standards
• GMO-free: certified in accordance with EC 1830/2003 – no genetically modified ingredients
• Non-irradiated: in accordance with EC 1999/2 – no ionising radiation applied
• Free from shellfish allergens: thanks to plant-based NaturGlux® glucosamine
• Guaranteed free from: preservatives, synthetic fragrances, colours and flavourings

Who is MSM GC suitable for?

MSM GC tablets have been developed for:

• People who want to support their natural mobility
• Active athletes and people with an active lifestyle
• Individuals looking for a combination supplement with MSM, glucosamine and chondroitin
• People with a shellfish allergy (thanks to plant-based glucosamine)
• Users who value patented branded ingredients and pharmaceutical quality
• Anyone looking for a quality product made in the Netherlands

Not suitable for

• Children and adolescents under 18 years of age
• Pregnant or breastfeeding women (consult a doctor first)
• People taking blood thinners (consult a doctor first due to chondroitin)
• People with an allergy to beef or beef products (due to ChondroPure® chondroitin from bovine trachea)
• Vegans and strict vegetarians (chondroitin is of animal origin) – choose MSM GC Vegan

Product features at a glance

• Four patented branded ingredients – OptiMSM®, NaturGlux®, ChondroPure® and Ester-C®
• Manufactured in the Netherlands – in our own FSSC 22000-certified factory
• Complete supply chain control – from raw material to finished product under direct supervision
• Extensively tested – for heavy metals and microbiological purity in independent laboratory
• GMO-free and non-irradiated – in accordance with EU legislation (EC 1830/2003 and EC 1999/2)
• Free from: preservatives, synthetic fragrances, colours and flavourings
• Tablet specifications: oblong-shaped, beige coated, 21.5 x 8.5 mm, 1340 mg per tablet
• Available in: 60 or 180 tablets per bottle

Important notices

A food supplement is not a substitute for a varied diet. A varied, balanced diet and a healthy lifestyle are important. This product is a food supplement (contains MSM, glucosamine, chondroitin, vitamins).

Safety: Consult a healthcare professional before using supplements in case of pregnancy, breastfeeding, medication use or illness.

Storage advice: Store in a dry place at room temperature, out of reach of small children.

Due to legal restrictions, we may not disclose all details about the possible effects of this food supplement. For content-related questions or personal advice, please contact us by phone: (+31) 070-345-0290. Or by email: info@kalahealth.eu.